J. Korbel, EMBL Heidelberg
Service center: Heidelberg Center for Human Bioinformatics – HD-HuB
The genome analysis server GEAR, which is part of EMBL’s de.NBI/ELIXIR-DE offerings, hosts applications for molecular biologists to analyze Sanger traces, discover mutations and design PCR primers across whole genomes of multiple species. This openly accessible web application server hosts pre-computed genome indices for human, mouse and other model organisms (e.g. drosophila or zebrafish).
To address the current COVID-19 health crisis and to allow other researchers to analyze SARS-CoV-2 genomes, GEAR has recently been expanded: The inclusion of the SARS-CoV-2 genome enables COVID-19 researchers to readily align and analyze COVID-19 chromatogram trace files (https://www.gear-genomics.com/sage/), including services to call SARS-CoV-2 mutations (https://www.gear-genomics.com/indigo/). GEAR enables the rapid detection of mutations with respect to the RefSeq SARS-CoV-2 sequence. For large-scale use cases, an open-source command-line application (https://github.com/gear-genomics/tracy) has been made available for Linux and Mac OSX at Bioconda (https://anaconda.org/bioconda/tracy).
For further information, visit https://www.gear-genomics.com/