Introduction: Embarking on the frontier of epigenetics, the upcoming de.NBI and GHGA training course, "DNA Methylation: Design to Discovery 2023," is poised to unravel the intricacies of bioinformatic processing in the realm of DNA methylation data. Led by esteemed educators, including Prof. Dr. Jörn Walter, Dr. Gilles Gasparoni, Dr. Thomas Hentrich, Nihit Aggarwal, Midhuna Maran and Lukas Laufer (HD HuB), this online workshop is set to be a beacon for researchers delving into the fascinating world of epigenomics.

Date and Location: Scheduled for November 2nd and 3rd, 2023, the course will be conducted online (MS Teams), providing a flexible and accessible learning environment for participants.

Course Overview: The workshop is meticulously designed to impart fundamental knowledge on the bioinformatic processing of DNA methylation data. The curriculum covers the nuances of various assays, emphasizing their respective benefits within the context of a standard experiment. The workshop will focus on theoretical and practical knowledge of sequencing data, guiding participants through the preprocessing of raw sequence reads, alignment, methylation calls, and the identification of differentially methylated sites or regions. Throughout this journey, the course delves into the intricate interplay of experimental settings, their impact on results, and the role of quality control in subsequent experiments. The latter part of the workshop shifts gears, concentrating on data evaluation and fostering meaningful interpretation. Practical sessions will be interspersed with insightful presentations, ensuring a well-rounded learning experience.

Learning Goals: Participants can expect to achieve the following learning goals:

  • Grasp the bioinformatic intricacies of DNA methylation.
  • Proficiently prepare and describe raw read files.
  • Gain basic skills in generating methylation calls and identifying differentially methylated regions.
  • Learn how to effectively evaluate DNA methylation data.

Prerequisites: To make the most of this course, participants should possess basic skills in Linux/bash and R.

Keywords: DNA methylation, Epigenomics, Bioinformatics

Tools: The workshop will leverage tools such as nf-core/methylseq, RnBeads, and methylSeekR to facilitate hands-on learning and practical applications.

Contact: For inquiries and additional information, please reach out to Nihit Aggarwal at This email address is being protected from spambots. You need JavaScript enabled to view it..

Registration: Interested participants are encouraged to register for the workshop by sending an email to This email address is being protected from spambots. You need JavaScript enabled to view it., providing the following details:

  • Name
  • E-mail
  • Specialization/Background
  • University/Institute

Don't miss this opportunity to delve into the fascinating world of DNA methylation and enhance your bioinformatics skills! Register now and unlock the secrets of epigenetic regulation.