The semantic lookup service (SemLookP) supports metadata annotation as well as data search in the area of translational medicine. This service is based on software developed by EBI: the Ontology Lookup Service (OLS) and the mapping service Ontology Xref Service (OxO). SemLookP concentrates on key ontologies for meta data annotation of human, mouse and rat omics data as well as clinical data. Furthermore, it integrates terminologies for referencing genes, gene variants, mRNAs, miRNAs and proteins for the organisms mentioned above. Connections between the concepts in different vocabularies are provided by the mapping service. Thereby, SemLookP allows to annotate research data and literature in a FAIR way.