Large-scale genome-wide association studies

Over the past decade, genetic epidemiology studies of complex polygenic traits and diseases have progressed from studying single genetic variants in candidate genes to investigating millions of genetic variants in genome-wide association studies (GWAS). Within de.NBI, this service project by IKMB Kiel University provides guidance for planning (and execution) of SNP array genotyping and hands-on support for large-scale quality control, variant annotation, imputation and association analysis of GWAS data. Our expertise builds on more than 90 completed GWA studies in the past 10 years. Besides providing specific GWAS services our service project may also help the users to obtain access to various large control data sets.

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