SMART
SMART (Simple Modular Architecture Research Tool) is a web-based resource for the identification and annotation of protein domains and the analysis of domain architectures. It detects more than 1,400 domain families, particularly in signalling, extracellular, chromatin-associated, and genetically mobile proteins. SMART provides extensive domain annotations, including phyletic distribution, functional class, tertiary structure information, and functionally important residues.
Key benefits
Identification and annotation of protein domains from sequence data
Detection of more than 1,400 curated domain families
Analysis of protein domain architectures and domain combinations
Rich domain annotations including function, structure, taxonomy, and conserved residues
Searchable database for proteins with specific domain combinations in defined taxa
Applications
Protein domain annotation and architecture analysis
Identification of functional regions in protein sequences
Comparative analysis of domain combinations across taxa
Exploration of signalling, extracellular, chromatin-associated, and mobile domains
Functional interpretation of newly characterized or predicted proteins
Intended use
SMART is intended for molecular biologists, bioinformaticians, protein scientists, and comparative genomics researchers who need to identify protein domains and explore domain architectures. It is particularly suited for users interested in functional protein annotation, conserved domain combinations, and the taxonomic distribution of domain families.
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