LipidCreator
LipidCreator is a software platform for the generation of targeted lipidomics mass spectrometry assays and in silico spectral libraries. It provides researchers with a semi-automated workflow for creating high-quality lipidomics methods, supporting a broad range of lipid classes and experimental designs. The software combines a comprehensive lipid knowledge base with flexible assay design capabilities and integrates seamlessly with established mass spectrometry analysis tools.
Key benefits
Supports more than 60 lipid classes across major lipid categories, including sphingolipids, glycerolipids, glycerophospholipids, sterols, and lipid mediators
Generates SRM and PRM assays for labeled and unlabeled lipid species
Creates high-quality in silico spectral libraries with collision energy optimization
Uses standardized lipid nomenclature according to community recommendations
Includes visual inspection of lipid and fragment structures for quality assurance
Available through both a graphical user interface (GUI) and command-line interface (CLI)
Fully integrates with Skyline for assay development and downstream data analysis
Applications
Development of targeted lipidomics assays for mass spectrometry
Generation of transition lists for SRM and PRM experiments
Creation of in silico spectral libraries for lipid identification
Optimization of collision energies for lipid fragmentation experiments
Standardization and translation of lipid nomenclature
Integration into automated workflows using Skyline, KNIME, or Galaxy
Intended use
LipidCreator is intended for lipidomics researchers, mass spectrometry users, and computational biologists who require reliable and standardized tools for assay development and lipid identification. It is particularly suited for laboratories performing targeted lipidomics experiments and researchers seeking vendor-independent workflows for method development, quality control, and data interpretation.
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