Dominik Kopczynski, Cristina Coman, Dominik Schwudke, Andrej Shevchenko, Robert Ahrends (BioInfra.Prot/LIFS)
DGMS 2017 / An der Halle 400 1, 24143 Kiel
Lipidomics studies in a comparative manner the identity, quantity, spatial and time dependent distribution of lipophilic and amphiphilic metabolites (lipids) in biological systems. Furthermore, lipidomics is a potent area in system biology that can be used together with genomics, transcriptomics, and proteomics to develop novel hypothesis and to answer biological questions arising from manifold scientific areas such as pathology, physiology, developmental biology, nutrition and biophysics.
This workshop is dedicated to give the participants an insight into several aspects of lipidomics studies including an introduction to lipid biology, mass spectrometric approaches and computational data analysis.
In the first part, a detailed introduction will be provided about lipids as central building blocks of life and their impact on energy storage, controlling the fluidity and curvature of membranes and signaling.
In the second part, the computational aspects are discussed. During the last years, several bioinformatics tools were developed with a strong focus on high resolution shotgun and targeted lipidomics. We present a selection of tools for the identification and analysis of lipids for both, targeted and untargeted mass spectrometric approaches including the tools LipidXplorer, LuxScore and Skyline for lipidomics.
Solid background in proteomics and lipidomics
Computational Lipidomics, Lipid workflows, shotgun lipidomics, targeted lipidomics
LipidXplorer, LipidCreator, LUX Score