eggNOG
eggNOG – Orthology and Functional Annotation Resource
eggNOG (evolutionary genealogy of genes: Non-supervised Orthologous Groups) is a database of hierarchically organized orthologous gene groups and their functional and evolutionary annotations. It provides orthology predictions across thousands of bacterial, archaeal, eukaryotic, and viral genomes, together with multiple sequence alignments, phylogenetic trees, and annotations from established functional resources. eggNOG supports comparative genomics and the transfer of functional information between evolutionarily related genes.
Key benefits
Hierarchically organized orthologous groups across numerous taxonomic levels
Broad coverage of bacterial, archaeal, eukaryotic, and viral genomes
Functional annotations linked to resources such as Gene Ontology, KEGG, UniProtKB, Pfam, CAZy, and CARD
Multiple sequence alignments and phylogenetic trees for orthologous groups
Interactive access through a web interface and bulk data downloads
Supports precise functional annotation based on orthology rather than general sequence similarity
Applications
Identification of orthologous genes and gene families
Functional annotation of genes and proteins
Comparative analysis of genomes, transcriptomes, and metagenomic gene catalogues
Investigation of gene-family evolution across taxa
Exploration of multiple sequence alignments and phylogenetic relationships
Transfer of functional annotations to newly sequenced organisms
Intended use
eggNOG is intended for comparative genomicists, evolutionary biologists, microbiologists, bioinformaticians, and researchers analysing genomes, transcriptomes, or metagenomes. It is particularly suited for users who need orthology-based functional predictions and evolutionary context for genes or proteins.
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