sORFdb
sORFdb is a dedicated database for short open reading frames (sORFs) and small proteins in bacteria. It integrates sequences from annotated genomes, curated protein resources, and experimentally supported small proteins, applies strict quality filtering, and provides an interactive web interface for searching, browsing, and downloading high-confidence small-protein data. The resource supports the exploration and annotation of bacterial small proteins that are often missed in standard genome annotation workflows.
Key benefits
Dedicated resource for bacterial sORFs and small proteins
Integrates data from annotated genomes, curated resources, and experimental evidence
Provides quality-filtered small-protein sequences and clustered protein families
Includes alignments, HMMs, metadata, and functional hints where available
Offers flexible search, browsing, and dataset download options
Applications
Discovery and annotation of bacterial small proteins
Comparative genomics across bacterial taxa
Enhancement of genome re-annotation workflows
Exploration of small-protein families, sequence features, and taxonomy
Prioritization of candidate small proteins for experimental validation
Intended use
sORFdb is intended for microbiome researchers, genome annotators, molecular microbiologists, bacterial geneticists, and bioinformaticians who study bacterial coding potential. It is particularly suited for users who need reliable, structured data on short open reading frames, small proteins, and small-protein families for annotation, comparison, or experimental follow-up.
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