BRENDA
BRENDA – Comprehensive Enzyme Information System
BRENDA is one of the world's most comprehensive databases of enzyme functional information. It provides manually curated data on enzymes classified according to the Enzyme Commission (EC) nomenclature, covering thousands of EC numbers across all domains of life. The database contains experimentally validated information extracted from primary literature, including enzyme functions, kinetics, substrate specificity, regulation, and optimal reaction conditions. All entries are critically reviewed by experts to ensure high data quality and consistency.
Key benefits
Comprehensive, manually curated enzyme information database
Covers enzymes from more than 8,800 EC numbers
Includes experimentally validated functional and kinetic data
Information on substrates, products, inhibitors, cofactors, and enzyme regulation
Provides pH and temperature optima as well as expression data
Links to metabolic pathways and related biological databases
Freely accessible through a user-friendly web interface
Applications
Enzyme function annotation and characterization
Identification of enzyme substrates, products, and inhibitors
Investigation of enzyme kinetics and catalytic properties
Metabolic pathway analysis and reconstruction
Comparative enzymology and systems biology
Support for biotechnology, metabolic engineering, and drug discovery
Intended use
BRENDA is intended for biochemists, molecular biologists, bioinformaticians, systems biologists, and biotechnology researchers seeking comprehensive, high-quality enzyme information. It is particularly suited for users requiring curated experimental data on enzyme function, kinetics, regulation, and metabolism for research, annotation, and computational modelling.
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