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SMART (Simple Modular Architecture Research Tool)

SMART is a web-based resource that enables the simple identification and extensive annotation of protein domains through sequence homology searches. By providing manually curated models for over 1,200 protein domains, SMART offers a comprehensive platform for researchers to explore and understand the structure and function of proteins.

Key Features
  • Protein Domain Annotation: SMART annotates protein sequences with known domain architectures, allowing researchers to identify functional regions within their proteins.
  • Manually Curated Models: The database contains over 1,200 manually curated models for protein domains, ensuring high accuracy and reliability in annotation results.
  • Genomic Mode: In this mode, SMART annotates proteins from completely sequenced genomes of 2,031 species, providing a basis for functional annotation and comparative genomics analysis.
  • Visual Exploration Tools: SMART offers flexible tools to visually explore protein domain architectures across sequences and organisms, facilitating the identification of conserved domains and novel domain combinations.
Benefits
  • Improved Protein Annotation: SMART provides accurate and comprehensive annotation of protein domains, enabling researchers to better understand protein function and structure.
  • Enhanced Comparative Genomics Analysis: By annotating proteins from multiple species, SMART facilitates comparative genomics analysis and the identification of conserved domains across different organisms.
  • Streamlined Research Workflow: With its intuitive interface and flexible tools, SMART simplifies the process of protein domain annotation and exploration, saving researchers time and effort.
Use Cases
  • Protein Structure-Function Analysis: Use SMART to identify functional regions within a protein sequence and understand their role in protein function and structure.
  • Comparative Genomics Analysis: Annotate proteins from multiple species using SMART's genomic mode to identify conserved domains and novel domain combinations.
  • Novel Protein Discovery: Utilize SMART to annotate newly discovered proteins and predict their potential functions based on known domain architectures.

Part of the Human Omics Analysis Toolbox.

Find this service in BioTools here.

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Funding: Neither development nor maintenance funded by de.NBI.