GenomeRNAi
GenomeRNAi is a comprehensive database that integrates results from RNA interference (RNAi) screening experiments in Drosophila and human cells. It provides detailed information on gene function, phenotypic effects, and experimental conditions, supporting researchers in functional genomics and systems biology. It also provides RNAi reagent information, along with an assessment as to their efficiency and specificity.
Key Benefits
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Centralized access: Curated repository of published RNAi phenotypes and experimental metadata.
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Cross-species data: Includes both Drosophila melanogaster and human gene screens for comparative analyses.
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Standardized annotations: Phenotypes are mapped to controlled vocabularies and ontologies for consistent search and interpretation.
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Integrated visualization: Links to gene networks, pathways, and image-based screening results for in-depth exploration.
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Interoperability: Cross-references to other databases such as Ensembl, FlyBase, and PubChem for seamless data integration.
Applications
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Discovery of gene functions and interactions through RNAi-based perturbation data.
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Comparative studies across species and cell types to identify conserved biological pathways.
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Target validation for high-throughput functional genomics and drug discovery projects.
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Training resource for bioinformatics and functional genomics workshops within the de.NBI network.
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