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EDGAR – Efficient Database Framework for Comparative Genome Analyses

EDGAR is a comprehensive online platform developed for the comparative analysis of prokaryotic genomes. It facilitates the identification of orthologous genes and the classification of genes into core genomes, pan-genomes, and singletons across multiple bacterial species.

Key Features

  • Core and Pan-Genome Calculation: EDGAR computes the core genome (genes shared across all selected genomes) and the pan-genome (the total gene repertoire within the selected genomes), providing insights into the conserved and variable gene content among related organisms.

  • Orthologous Gene Identification: The platform identifies orthologous genes across different genomes, aiding in the study of gene conservation and evolutionary relationships.

  • Visualization Tools: EDGAR offers various visualization features, including synteny plots to display gene order conservation and Venn diagrams to represent shared and unique genes among genomes.

  • Functional Categorization: The platform enables users to analyze and categorize genomic data based on functional categories using datasets from KEGG, COG, and GO, enhancing the understanding of gene functions within the genomes.

Tools

  • Genome Browser: EDGAR includes a genome browser that allows users to analyze orthologous genes in their genomic context, facilitating the study of gene neighborhoods and synteny at a detailed level.

  • Data Export: Users can download data in various formats, including FASTA and annotation files, for further analysis.

Applications

  • Comparative Genomics Research: EDGAR serves as a valuable resource for comparative genomics studies, enabling researchers to analyze the evolution of gene content and organization across different bacterial species.

  • Functional Genomics: By categorizing genes into functional groups, EDGAR assists in understanding the roles of genes within the core and accessory genomes.

Target Audience

EDGAR is designed for researchers in microbiology, genetics, and bioinformatics, particularly those interested in the comparative analysis of bacterial genomes and the study of gene conservation, evolution, and function.

For more information and access to EDGAR, please visit the official website:

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Funding: Development and maintenance partially funded by de.NBI