DESeq2
DESeq2 is an R/Bioconductor package for differential expression analysis of high-throughput sequencing assays. It provides a comprehensive toolset for analyzing various types of sequencing data, including RNA-seq, ChIP-Seq, 4C-Seq, ribosome profiling, CLIP, metagenomics, and HT-CRISPR screens.
Key Features
- Differential Expression Analysis : DESeq2 performs differential expression analysis based on the Gamma-Poisson distribution, providing a robust and sensitive method for identifying differentially expressed genes.
- Support for Multiple Assay Types : The package supports a wide range of high-throughput sequencing assays, making it a versatile tool for various applications in genomics and transcriptomics research.
Use Cases
- RNA-seq Analysis : Use DESeq2 to analyze RNA-seq data and identify differentially expressed genes between conditions or time points.
- ChIP-Seq Analysis : Apply DESeq2 to ChIP-Seq data to investigate changes in protein-DNA interactions across different conditions.
- Metagenomics Analysis : Utilize DESeq2 for differential expression analysis of metagenomic data, providing insights into the functional potential of microbial communities.
Availability
DESeq2 is available as an R/Bioconductor package and can be downloaded from the Bioconductor website.
Part of the Human Omics Analysis Toolbox.
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Funding: Neither development nor maintenance funded by de.NBI