Heidelberg Center for Human Bioinformatics (HD-HuB)

de.NBI Services offered by HD-HuB de.NBI Training offered by HD-HuB

About

The Heidelberg Center for Human Bioinformatics (HD-HuB) bundles bioinformatics expertise from research groups at five established research institutions in Heidelberg, Berlin and Saarbrücken:

• European Molecular Biology Laboratory (EMBL, research groups Bork, Huber, Korbel)
• German Cancer Research Center (DKFZ, research group Brors, Boutros, core facility Buchhalter)
• Heidelberg University (research groups Russell, Rohr, Erfle)
• BIH at Charité (research groups Eils, Ishaque, Wagener, Twardziok)
• Saarland University (research groups Walter, Müller)

Services

Within the de.NBI network, HD-HuB focuses on the following core application areas:

• Human Genetics and Genomics
  HD-HuB provides resources for efficiently collecting, organizing, and analyzing highly complex sequencing data used in human genetics and genomics research. This includes the development of novel bioinformatics tools and pipelines for analyzing next-generation sequencing data, such as exome and whole-genome sequences, as well as RNA sequencing (RNAseq).
• Metagenomics
  Efforts in this area focus on improving and developing bioinformatics tools for applications such as taxonomic and functional profiling of microbiomes, genome and metagenome annotation, and associating microbiome composition with host phenotypes.
• Systematic Phenotyping of Human Cells
  HD-HuB offers computational workflows for the systematic phenotyping of human cells, including the automated analysis and visualization of large-scale high-content screening data. These workflows are delivered through centralized, web-based platforms and are supported by a database that enables integration and visualization of multi-phenotype data.
• Computational Epigenetics
  The network develops analysis workflows for epigenetics research, particularly focused on DNA methylation data generated by whole-genome bisulfite sequencing (WGBS) and methylation-specific oligonucleotide arrays.
• Single Cell and Spatial Omics
  HD-HuB supports the integration and analysis of high-resolution data from single-cell and spatial omics technologies, enabling new insights into cellular heterogeneity and spatial tissue organization.
• de.NBI Cloud Services
  The de.NBI Cloud is a federated and flexible cloud infrastructure that provides access to compute and storage resources for academic research. It enables the use of bioinformatics tools and facilitates the execution of computational workflows across all domains and application areas. The infrastructure is distributed across eight institutional sites, including four within the HD-HuB service center: Heidelberg University, DKFZ Heidelberg, BIH at Charité Berlin, and EMBL Heidelberg.

In each of these application areas, HD-HuB members provide extensive user support, contribute essential computational resources, and are actively involved in training and educational initiatives.

Developments

HD-HuB is actively engaged in the development and refinement of bioinformatics workflows and pipelines tailored to human genomics, metagenomics, and epigenomics data analysis. This includes adapting existing tools to new sequencing technologies and data types, optimizing scalability and interoperability, and integrating workflows into user-friendly platforms.

In the area of single-cell analysis and bioimage data, efforts focus on developing automated analysis tools and databases to support large-scale, high-throughput imaging data. This includes advances in machine learning-based image analysis and the integration of image-derived phenotypes with other omics data.

Across all application areas, HD-HuB contributes to the development of training formats and materials, so that courses and workshops evolve alongside the tools and services.

Project Management

Dr. Peer Bork (Coordinator)
European Molecular Biology Laboratory (EMBL)
Meyerhofstr. 1
69117 Heidelberg
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Prof. Dr. Roland Eils (Deputy Coordinator)
Berlin Institute of Health at Charité
Center of Digital Health
Luisenstr. 65
10117 Berlin
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Dr. Sina Barysch (Project Management)
European Molecular Biology Laboratory (EMBL)
Meyerhofstr. 1
69117 Heidelberg
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Posters