Heidelberg Center for Human Bioinformatics (HD-HuB)
The staff of the Service Center "Heidelberg Center for Human Bioinformatics" (HD-HuB)de.NBI Services offered by HD-HuB de.NBI Training offered by HD-HuB
About
The Heidelberg Center for Human Bioinformatics (HD-HuB) bundles bioinformatics expertise from research groups at four established research institutions in Heidelberg and Berlin: European Molecular Biology Laboratory (EMBL, research groups Bork, Huber, Korbel, Zeller), the German Cancer Research Center (DKFZ, research group Boutros, core facility Buchhalter), and Heidelberg University (research groups Russell, Rohr, Erfle) and Charité / Berlin Institute of Health (BIH, research groups Eils, Ishaque). Since November 2016 a partner project on computational epigenetics (de.NBI-epi) is associated with HD-HuB. de.NBI-epi is coordinated by Jörn Walter (University of Saarland) and Benedikt Brors (DKFZ).
Services
Within the de.NBI network, HD-HuB focuses on four main application areas: 1) providing resources for efficiently collecting, organizing and analyzing highly complex sequencing data for research in human genetics and genomics and establishing novel bioinformatics tools and pipelines for the analysis of next-generation sequencing data of various kinds, such as exome and whole-genome sequences and RNAseq; 2) improving and developing new bioinformatics tools for various applications in the area of metagenomics, such as taxonomic and functional microbiome profiling, genome and metagenome annotation, and associating microbiome composition with host phenotypes; 3) providing computational workflows for systematic phenotyping of human cells including automated analysis and visualization of large-scale high-content phenotype screening data of human cells based on central web-based workflows and a database to integrate and visualize multi-phenotype data, and 4) providing analysis workflows for computational epigenetics research, in particular for DNA methylation data collected by means of whole-genome bisulfite sequencing (WGBS) and hybridization to methylation-specific oligonucleotide arrays. In all four areas, HD-HuB/de.NBI-epi members provide resources and support, and will actively engage in training activities.
Developments
Activities within HD-HuB aim at the provision of workflows and pipelines for the analysis of sequencing data in the context of human genomics, metagenomics, and epigenomics and at the provision of automated tools and databases for the analysis of bioimage data for single cell analysis. In all four application areas, HD-HuB provides courses and workshops for hands-on training of basic and expert users on the offered tools and services.
Project Management
Dr. Peer Bork (Coordinator)
European Molecular Biology Laboratory (EMBL)
Meyerhofstr. 1
69117 Heidelberg
Prof. Dr. Roland Eils (Deputy Coordinator)
Berlin Institute of Health at Charité
Center of Digital Health
Luisenstr. 65
10117 Berlin
Dr. Sina Barysch (Project Management)
European Molecular Biology Laboratory (EMBL)
Meyerhofstr. 1
69117 Heidelberg
HD-HuB Update
Posters
