Heidelberg Center for Human Bioinformatics (HD-HuB)

hdhubThe staff of the Service Center "Heidelberg Center for Human Bioinformatics" (HD-HuB)

de.NBI Services offered by HD-HuB de.NBI Training offered by HD-HuB

 

About

The Heidelberg Center for Human Bioinformatics (HD-HuB) bundles bioinformatics expertise from research groups at four established research institutions in Heidelberg and Berlin: European Molecular Biology Laboratory (EMBL, research groups Bork, Huber, Korbel, Zeller), the German Cancer Research Center (DKFZ, research group Boutros, core facility Buchhalter), and Heidelberg University (research groups Russell, Rohr, Erfle) and Charité / Berlin Institute of Health (BIH, research groups Eils, Ishaque). Since November 2016 a partner project on computational epigenetics (de.NBI-epi) is associated with HD-HuB. de.NBI-epi is coordinated by Jörn Walter (University of Saarland) and Benedikt Brors (DKFZ)

Services

Within the de.NBI network, HD-HuB focuses on four main application areas: 1) providing resources for efficiently collecting, organizing and analyzing highly complex sequencing data for research in human genetics and genomics and establishing novel bioinformatics tools and pipelines for the analysis of next-generation sequencing data of various kinds, such as exome and whole-genome sequences and RNAseq data; 2) improving and developing new bioinformatics tools for various applications in the area of metagenomics, such as microbiome profiling, genome and metagenome annotation, associating microbiome composition with host phenotypes and microbial community profiling; 3) providing pipelines in the application area systematic phenotyping of human cells for automated analysis and visualization of large-scale high-content phenotype screening data of human cells based on central web-based workflow units for high-content screening and image processing and a database to integrate and visualize multi-phenotype data, and 4) providing workflows for analysis of profiling data for computational epigenetics research, in particular from measurements of DNA methylation by means of whole-genome bisulfite sequencing (WGBS) and from hybridization to methylation-specific oligonucleotide arrays. In all four areas, HD-HuB/de.NBI-epi members provide resources and support, and will actively engage in training activities.

Developments

Activities within HD-HuB aim at the provision of workflows and pipelines for the analysis of sequencing data in the context of human genomics, metagenomics, and epigenomics and at the provision of automated tools and databases for the analysis of bioimage data for single cell analysis. In all four application areas, HD-HuB provides courses and workshops for hands-on training of basic and expert users on the offered tools and services.

Project Management

Dr. Peer Bork (Coordinator)
European Molecular Biology Laboratory (EMBL)
Meyerhofstr. 1
69117 Heidelberg
Tel: +49 6221 387 8361
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Prof. Dr. Roland Eils (Deputy Coordinator)
Berlin Institute of Health and Charité
Anna-Louisa-Karsch-Str. 2
10178 Berlin  
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Christian Lawerenz (Operational Management)
Berlin Institute of Health
Anna-Louisa-Karsch-Str. 2
10178 Berlin
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Ulrike Trojahn (Project Management)
European Molecular Biology Laboratory (EMBL)
Building 1A, Room 118
Meyerhofstraße 169117 Heidelberg
Tel: +49 6221 387 8369
Fax: +49 6221 387 8575
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Posters

HD-HuB Overview     HD-HuB Genomics    HD-HuB Metagenomics    HD-HuB Systematic Phenotyping    HD-HuB deNBI-epi